Process & Quality Data Connected.
Available. Validated.
The Manufacturing Intelligence Platform (MIP) by Appliant is the central nervous system for modern manufacturing. By unifying disparate data from the shopfloor to the C-suite, MIP transforms raw data into actionable insights while maintaining the highest standards of regulatory integrity.
The MIP Application Suite
The MIP is a platform that grows with you. Once the foundation is laid, you can layer these specialized applications to drive specific performance outcomes.
eLogbook
- Automated Status Tracking: Real-time visibility into room/equipment status.
- Digital Signatures: Compliant approvals for cleaning and maintenance.
- ERP Sync: Automatically triggers maintenance cycles based on usage.
Paper-on-Glass
- Guided Workflows: Enforces SOP adherence with digital step-by-step guides.
- Real-time Validation: Instant data entry checks to eliminate out-of-spec values.
- Multimedia Support: Attach photos or videos for enhanced operator training.
Planner
- Constraint-Based:Optimizes schedules based on labor and machine readiness.
- What-If Analysis: Simulates the impact of rush orders or downtime.
- Dynamic Response: Adjusts schedules instantly based on live shopfloor data.
Machine (PLC Connection)
- Protocol Agnostic: Native support for OPC-UA, MQTT, and Modbus.
- High-Frequency Capture: Records sub-second variables for root cause analysis.
- Automatic OEE: Calculates performance metrics without manual input.
Electronic Batch Record (eBR)
- Exception Flags: Automatically highlights deviations for faster release.
Dynamic Logic:Automated yield and material reconciliation calculations. - Full Genealogy:Trace materials from raw intake to finished goods
Utilities App
- Integrated BMS/EMS: Centralizes monitoring of Building Management (HVAC, room pressure) and Environmental Management Systems (temp/humidity) directly within the production context.
- Clean & Black Utilities Connectivity: Real-time visibility into the status and quality of “Clean” utilities (WFI, Purified Water, Clean Steam) and “Black” utilities (Compressed Air, Chilled Water, Electricity).
- Compliance-Driven Alarming: Automated alerts and deviation logging for environmental excursions, ensuring that any impact on product quality is instantly captured in the MIP.
PAT (Process Analytical Technology)
- In-line Monitoring: Real-time CQA analysis using NIR or Raman sensors.
- Closed-Loop Control: Automatic parameter adjustments via the PLC.
- Quality Prediction: Multivariate analysis to predict batch outcomes early.
PQR (Product Quality Review)
- Automated Aggregation: Pulls multi-system data (LIMS/QMS) instantly.
- Trend Analysis: Statistical visualization of process capability (Cpk / Ppk).
- Compliance Ready: Generates submission-ready PDFs for FDA/EMA.
A proven track record.
Particle counters connected to the EMS app (Environmental Management System) to secure process quality in advanced therapies.
Holding time reduction between batches thanks to instrument calibration checking via Netilion Platform.
Standardize process control, adding the GMP compliance layer and batch control for radiopharma production.
Adding the GMP compliance layer, data contextualization and batch control to increase process robustness.
Breaking data silos to interconnect Raman’s spectrum data, process bioreactor data and off-line data.
100% data capture to ensure process robustness in personalized ATMPs and to establish a reliable baseline for continuous treatment improvement.
100% process fulfillment, with 0 missing entries thanks to an end-to-end integration including ERP and QMS.
75% faster Time-To-Market à batch release process from 11 days down to 2 days.
100% Data Integrity and Audit Trails fulfillment, of the whole entire site from one-single validated platform “Cocoon – MIP’